2. Signaling Pathways
  3. GPCR/G Protein
  4. Guanylate Cyclase

Guanylate Cyclase

Guanylate Cyclase

Related Products

PDF 0.54 MB

Guanylate cyclase (guanylyl cyclase, GC), which catalyzes the formation of cGMP from GTP, exists in both the soluble and particulate fractions of cells. Guanylyl cyclases signal via the production of the second messenger cGMP.

The GC family consists of particulate GC (pGC) and a nitric oxide-activated soluble GC (sGC). Seven pGC isoforms have yet been found (pGC-A to pGC-G). pGCs are activated by binding of peptide ligands to their extracellular domains. sGC is a receptor for endogenous and exogenous nitric oxide and is activated several-fold upon its binding, constituting a core enzyme in the nitric oxide signal transduction pathway. cGMP generated by sGC is an important second messenger that regulates activity of several enzymes triggering such important physiologic reactions as vasodilation, smooth muscle relaxation and platelet aggregation.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-117443
    IWP-051
    		Agonist
    IWP-051 is an agonist for soluble guanylate cyclase with an EC50 of 290 nM. IWP-051 stimulates the generation of cGMP, and exhibits the synergistic effect with NO. IWP-051 exhibits good pharmacokinetic characteristics in rats.
    IWP-051
  • HY-137325
    2-Chloro-ATP
    		Inhibitor
    2-Chloro-ATP is a soluble guanylate cyclase inhibitor that increases intracellular calcium concentration at low concentrations through a mechanism independent of inositol phosphate production.
    2-Chloro-ATP
  • HY-14779S3
    Riociguat-d3
    		Activator
    Riociguat-d3 (BAY 632521-d3) is deuterium labeled Riociguat. Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.
    Riociguat-d<sub>3</sub>
  • HY-109066R
    Olinciguat (Standard)
    		Activator
    Olinciguat (Standard) is the analytical standard of Olinciguat (HY-109066). This product is intended for research and analytical applications. Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay.
    Olinciguat (Standard)
  • HY-136781
    A-350619
    		Activator
    A-350619 is a novel sGC activator. A-350619 increases intracellular cGMP levels. A-350619 significantly induces penile erection.
    A-350619
  • HY-14927R
    Lificiguat (Standard)
    		Activator
    Lificiguat (Standard) is the analytical standard of Lificiguat. This product is intended for research and analytical applications. Lificiguat binds to the β subunit of soluble guanylyl cyclase(sGC) with Kd of 0.6-1.1 μM in the presence of CO.
    Lificiguat (Standard)
  • HY-164228
    Vericiguat impurity-3
    		Control
    Vericiguat impurity-3 is an impurity of Vericiguat (HY-16774). Vericiguat (BAY1021189) is a potent, orally available and soluble guanylate cyclase stimulator.
    Vericiguat impurity-3
  • HY-16774R
    Vericiguat (Standard)
    		Activator
    Vericiguat (Standard) is the analytical standard of Vericiguat. This product is intended for research and analytical applications. Vericiguat (BAY1021189) is a potent, orally available and soluble guanylate cyclase stimulator.
    Vericiguat (Standard)
  • HY-107548
    A-350619 hydrochloride
    		Activator
    A-350619 hydrochloride is a soluble guanylate cyclase (sGC) activator. A-350619 hydrochloride can be used in the study of erectile dysfunction.
    A-350619 hydrochloride
  • HY-16774S2
    Vericiguat-d6
    		Activator
    Vericiguat-d6 (BAY1021189-d6) is deuterium labeled Vericiguat. Vericiguat (BAY1021189) is a potent, orally available and soluble guanylate cyclase stimulator.
    Vericiguat-d<sub>6</sub>
  • HY-12376R
    BAY 41-2272 (Standard)
    		Activator
    BAY 41-2272 (Standard) is the analytical standard of BAY 41-2272. This product is intended for research and analytical applications. BAY 41-2272 is an orally active and soluble guanylate cyclases (sGC) activator, which increases sGC activity by 400-fold in synergy with NO. BAY 41-2272 potently unloaded the heart, increased cardiac output, thus can be used for cardiovascular diseases research.
    BAY 41-2272 (Standard)
  • HY-17584R
    Linaclotide (Standard)
    		Agonist
    Linaclotide (Standard) is the analytical standard of Linaclotide. This product is intended for research and analytical applications. Linaclotide is a potent and selective guanylate cyclase C agonist; developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation.
    Linaclotide (Standard)
  • HY-W013386R
    LY83583 (Standard)
    		Inhibitor
    LY83583 (Standard) is the analytical standard of LY83583 (HY-W013386). This product is intended for research and analytical applications. LY83583 is inhibitor of soluble guanylate cyclase (sGC) with the ability to target the cGMP signaling pathway. LY83583 inhibits the kinase activity-related proliferation of tumor cells by inducing the Cdk inhibitor p21. LY83583 can be used for the study of cancers (colorectal cancer, breast cancer and melanoma) and cardiovascular disease.
    LY83583 (Standard)
  • HY-161681
    Formycin triphosphate
    		Activator
    Formycin triphosphate is a fluorescent analogue of ATP which on binding to enzyme active sites exhibits enhanced fluorescence. Formycin triphosphate is an ATP-competitive chicken liver pyruvate carboxylase inhibitor. Formycin triphosphate potentiates atrial natriuretic factor (ANF)-stimulated guanylate cyclase activity with an EC50 at about 90 μM and inhibits ATP-stimulated guanylate cyclase activity with an IC50 at about 100 μM.
    Formycin triphosphate
  • HY-14181AR
    Cinaciguat hydrochloride (Standard)
    		Activator
    Cinaciguat (hydrochloride) (Standard) is the analytical standard of Cinaciguat (hydrochloride). This product is intended for research and analytical applications. Cinaciguat hydrochloride is a potent soluble guanylate cyclase (GC) activator with EC50 of 15 nM in platelets.
    Cinaciguat hydrochloride (Standard)
  • HY-14181R
    Cinaciguat (Standard)
    		Activator
    Cinaciguat (Standard) is the analytical standard of Cinaciguat. This product is intended for research and analytical applications. Cinaciguat is an activator of guanylate cyclase (sGC), and used for acute decompensated heart failure.
    Cinaciguat (Standard)
Cat. No. Product Name / Synonyms Application Reactivity